This book provides recommendations for thermal and structural modelling of spacecraft structures for predicting thermoelastic responses. It touches upon the related aspects of the finite element and thermal lumped parameter method. A mix of theoretical and practical examples supports the modelling guidelines. Starting from the system needs of instruments of spacecraft, the reader is supported with the development of the practical requirements for the joint development of the thermal and structural models. It provides points of attention and suggestions to check the quality of the models.The temperature mapping problem, typical for spacecraft thermoelastic analysis, is addressed. The principles of various temperature mapping methods are presented. The prescribed average temperature method, co-developed by the authors, is discussed in detail together with its spin-off to provide high quality conductors for thermal models.The book concludes with the discussion of the application of uncertainty assessment methods. The thermoelastic analysis chain is computationally expensive. Therefore, the 2k+1 point estimate method of Rosenblueth is presented as an alternative for the Monte Carlo Simuation method, bringing stochastic uncertainty analysis in reach for large thermoelastic problems.