The 28th volume of Recent Advances in Pediatrics presents cutting-edge topics in pediatrics through 40 peer-reviewed chapters from 50 experts. It covers a wide range of subjects, starting with artificial intelligence, smartphones, and the emerging threat of monkeypox alongside ongoing concerns of COVID-19. Pediatric neurology is addressed with a focus on epilepsy, movement disorders, and autism, while key cardiovascular issues such as congenital heart disease, pulmonary hypertension, and anticoagulation in venous thromboembolism are also discussed. The volume highlights pulmonology topics including acute respiratory distress syndrome, tuberculosis, and bronchiolitis obliterans, and nephrology issues like urinary tract infections, kidney injury, and chronic kidney disease. Infantile cholestasis, emphasizing early detection and treatment, is also explored. Other topics include anticoagulation, gene therapy for sickle cell disease, hemophilia management, ambiguous genitalia, and the management of pediatric septic shock. In addition, the volume addresses cytokine storm, autoimmune encephalitis, eating disorders, thiamine deficiency, the growing role of point-of-care ultrasound (POCUS), umbilical cord and human milk banking, and the ethical challenges of managing genetic disorders. Each chapter offers state-of-the-art insights into modern pediatric care.