The current edition is mainly written to fulfil the need of Indian Medical Graduates to pursue the NMC’S new competency-based medical education (CBME) curriculum. Accordingly, a new section of Systemic Parasitology based on individual competencies comprising of individual systems, such as cardiovascular system, respiratory, central nervous systems, etc., have been added. At the end of each systemic chapter, there are few case-based studies with answers at the end of the section as per CBME. Many new photographs, CT scan, X-ray and USG images have been added in the past edition.In the current edition, many new MCQs, tables, flowcharts have been added for better comprehension of the subject. At the end of the each chapter, the must-know facts are given as “Key Points” for quick recapitulation. Important Multiple-Choice Questions from various university examinations papers have been added to test and reinforce the understanding of the topics by the students. Recent advances, such as vaccinology of malaria and leishmaniasis, malaria drug resistance, new treatment protocols and latest diagnostic techniques of different parasitic infections are the salient features of the book. Like the previous edition, present edition is also designed in a colorful format, which can be easily read and comprehended. Important points and terms have been highlighted by making them bold and italic.