This book introduces transdermal drug delivery and the developments that have taken place in various transdermal drug delivery techniques including the system-level design approach of a novel miniaturized medical device to offer precise and painless drug delivery via a skin-based transdermal route. It discusses the microelectromechanical systems (MEMS)-based fabrication technique and the design, fabrication and characterization of different MEMS-based components like microneedles and micropumps. It further includes a MEMS-based component micropump with design, analysis, fabrication and characterization of the transdermal drug delivery device and challenges encountered in the design improvements.Features:Summarizes transdermal drug delivery systems especially with a focus on MEMS and microneedles, including theoretical conceptsEmphasizes system integration by describing simulation and design techniques as well as experimental fabricationDiscusses system-level integration for miniaturized therapeutic devicesIncludes working simulation models covering microneedles and micropump analysisExplores future direction in development of pertinent devicesThe book is aimed at researchers, professionals, and graduate students in biomedical engineering, microelectronics, micro-electro-mechanical-systems, and drug delivery.