This book contains articles dealing with discovery, structure elucidation and elegant synthetic strategies developed for natural products, with an emphasis on the structure activity relationship of bioactive natural products. The contributions, made by some of the world's leading scientists in the field, should be of great interest to the readers. The topics are selected carefully since bioactive natural products are clinically useful pharmaceuticals or the primary compounds under extensive medicinal chemistry exploration. The book provides examples with updated research results which can spur graduate students' interests in bioactive natural products research. It also brings a historical perspective to the chemistry and biology of some selected bioactive compounds, a technique which could inform researchers about the process of developing pharmaceuticals, from discovery to application as drugs. Table of Contents:PrefaceContributorsPart I: HPLC Theory and PracticeIntroduction (Yuri Kazakevich and Rosario LoBrutto) HPLC Theory (Yuri Kazakevich) Stationary Phases (Yuri Kazakevich and Rosario LoBrutto)Reversed-Phase HPLC (Rosario LoBrutto and Yuri Kazakevich)Normal-Phase HPLC (Yong Liu and Anant Vailaya) Size-Exclusion Chromatography (Yuri Kazakevich and Rosario LoBrutto) LC/MS: Theory, Instrumentation and Applications to Small Molecules (Guodong Chen, Li-Kang Zhan and Birendra N. Pramanik)Method Development (Rosario LoBrutto). Method Validation (Rosario LoBrutto and Tarun Patel) Computer-Assisted HPLC and Knowledge Management (Yuri Kazakevich, Michael McBrienand Rosario LoBrutto) Part II: HPLC in the Pharmaceutical IndustryThe Expanding Role of HPLC in Drug Discovery (Daniel B. Kassel) Role of HPLC in Preformulation (Irina Kazakevich)The Role of Liquid Chromatography-Mass Spectrometry in Pharmacokinetics and Drug Metabolism (Ray Bakhtiar, Tapan K. Majumdarand Francis L. S. Tse)Role of HPLC in Process Development (Richard Thompson and Rosario LoBrutto)Role of HPLC During Formulation Development (Tarun S. Patel and Rosario LoBrutto) The Role of HPLC in Technical Transfer and Manufacturing (Joseph Etse) Part III: Hyphenated Techniques and Specialized HPLC SeparationsDevelopment of Fast HPLC Methods (Anton D. Jerkovich and Richard V. Vivilecchia) Temperature as a Variable in Pharmaceutical Applications (Roger M. Smith)LC/MS Analysis of Proteins and Peptides in Drug Discovery (Guodong Chen, Yan-Hui Liuand Birendra N. Pramanik) LC-NMR Overview and Pharmaceutical Applications (Maria Victoria Silva Elipe)Trends in Preparative HPLC (Ernst Kuesters)Chiral Separations (Nelu Grinberg, Thomas Burakowski and Apryll M. Stalcup)Chemical and Drug Compound IndexSubject Index