This textbook provides an introduction to the fundamental and applied aspects of biophysics foradvanced undergraduate and graduate students of physics, chemistry, and biology.The application of physics principles and techniques in exploring biological systems has longbeen a tradition in scientific research. Biological systems hold naturally inbuilt physical principlesand processes which are popularly explored. Systematic discoveries help us understand the structuresand functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and eventhe physiological systems of animals and plants. Utilizing a physics- based scientific understandingof biological systems to explore disease is at the forefront of applied scientific research.This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizonsand directions of research. It contains models based on both classical and quantum mechanicaltreatments of biological systems. It explores diseases related to physical alterations in biomolecularstructures and organizations alongside drug discovery strategies. It also discusses the cutting- edgeapplications of nanotechnologies in manipulating nanoprocesses in biological systems.Key Features¢ Presents an accessible introduction to how physics principles and techniques can be used tounderstand biological and biochemical systems.¢ Addresses natural processes, mutations, and their purposeful manipulation.¢ Lays the groundwork for vitally important natural scientific, technological, and medicaladvances.Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate aboutinvestigating biological and biochemical processes utilizing physics principles and techniques. Heis a professor of biophysics at King Saud Universitys Biochemistry Department in the College ofScience, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child LifeDevelopment Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology ofIon Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also publishedabout 50 peer- reviewed articles and several patents, edited two books, and has been servingon the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has heldresearch and academic ranks at Bangladesh University of Engineering & Technology, Universityof Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College ofCornell University (USA), and University of Alberta (Canada). During 2013“ 2018 he also served asa Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology,of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor ofScience (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.