Several innovations have revolutionized the healthcare sector in recent years. Digitalization, personalized medicine, Advanced Cell, and Tissue Engineering, and AI are some keywords associated with improving the prevention and therapy of diseases, i.e., to combat our crisis of non-communicable diseases. One of the key areas where innovation has had a profound impact is precision medicine. Precision medicine seeks to understand the unique genetic, environmental, and lifestyle factors contributing to an individual's health and disease risk. Through advancements in genomics, proteomics, and other molecular profiling techniques, healthcare providers can now gain a deeper understanding of a patient's molecular makeup. This knowledge allows for targeted interventions and therapies tailored to the specific needs of each individual, maximizing treatment efficacy and minimizing adverse effects.Furthermore, the development of advanced diagnostic tools has greatly enhanced the accuracy and efficiency of disease detection and monitoring. Innovations such as high-resolution imaging technologies, wearable sensors, and liquid biopsies have revolutionized the diagnostic landscape. Integrating artificial intelligence (AI) and machine learning (ML) algorithms has further augmented the capabilities of healthcare management and precision medicine capabilities. This book aims to bring up-to-date new ideas, opinions, development, and critical issues in healthcare and personalized medicine. We are interested in relevant articles covering a broad range of topics, such as ¢       Advances in medical devices¢       Digitalization and data-driven technologies ¢       AI and algorithm-based drug development (molecule building, enhancement, clinical trials)¢       Diagnostic imaging¢       Personalized medicine¢       Nutrition¢       Oral health care¢       Healthcare management in certain diseases and population groups¢       Regulatory developments¢       Data management¢       Digital HealthcareChapter Unlocking the Code of Innovation: TRIZ Theorys Blueprint for Precision Medicine Breakthroughs islicensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). For further details see licence information in the chapter.