The rapid growth of the global aging population brings with it unprecedented challenges and opportunities in healthcare. As older adults increasingly live with multiple chronic conditions, often managed through complex medication regimens, the need for rational prescribing practices becomes ever more critical. The elderly population's unique physiological changes, vulnerabilities to adverse drug reactions, and frequent exposure to polypharmacy demand tailored approaches to ensuring safe, effective, and ethical medication use.\n"ICP/API Guidelines on Rational Prescribing Practices in the Elderly" is designed to address these challenges comprehensively. This book provides a roadmap for healthcare professionals to navigate the complexities of prescribing for elderly patients, balancing the need for therapeutic efficacy with the imperative to minimize harm.\nThe chapters in this book reflect a wide range of expertise and evidence-based strategies. From understanding the physiological changes that influence drug pharmacokinetics and pharmacodynamics in aging to exploring practical tools like the Beers Criteria and STOPP/START frameworks, each section is crafted to enhance clinical decision-making. The book also delves into critical issues such as deprescribing, managing drug–drug interactions, and addressing ethical and legal considerations in elderly care.\nNonpharmacological strategies, personalized medication management, and detailed case studies further enrich the discussion, offering actionable insights into improving the quality of life for older adults. By presenting a holistic view of rational prescribing, this book aims to empower healthcare providers to adopt patient-centered approaches, foster shared decision-making, and ensure equitable, ethical, and effective care for elderly populations.