It is a ready to use, concise compilation of important topics for postgraduate students in pathology. It is a collection of topics from the very successful SPARRC programme (Sri Ramachandra Pathology Annual Rapid Review Course) being conducted for the eleventh consecutive year. It includes key points in histopathology of major lesions from each system and other fundamental topics of practical importance such as autopsy, special stains and immunohistochemistry. Various topics in hematology, cytology and transfusion medicine have also been discussed. The current (sixth) edition is an updated version designed to include the guidelines of examination as per NMC pattern which has been elucidated at the end of the book. On popular demand three new chapters Artificial intelligence and Digital Pathology, Overview of Transplant Pathology and Biopsy Interpretation with IHC Markers have been included in this edition. Current topics pertaining to molecular diagnosis, flow cytometry, and FISH have been updated. Chapters FAQs in Histotechniques and Current Updates in Pathology and Potpourri of Gross Cases and Approach to Gross Differential Diagnosis from earlier edition have been further expanded. This edition has improvised on the existing chapters and updated the current criteria. In addition, a ready-reckoner of current updated WHO classification of tumors is presented. This Handbook will be a valuable quick reference for all the postgraduate students in pathology and a friendly guide to the young faculty who wish to refurbish their knowledge in pathology.