In the world of transportation, fatigue is a silent killer that can affect us all. Understanding fatigue, including how to manage it to minimize safety risk, is of great importance. However, while it is one thing to recognize that fatigue is a critical safety issue, it is quite another to set up a successful, scientifically informed fatigue risk management programme. This book is here to help. It has been carefully designed as a comprehensive reference point, bringing together international expertise from leaders in fatigue science, and showcasing valuable insights from transportation industry practitioners. The 40 authored chapters are divided into six sections, to better understand fatigue science, the consequences of fatigue in transportation, contributors to fatigue, managing fatigue and promoting alertness, real world case studies of fatigue management in practice, and future perspectives. While it is possible to read each chapter in isolation, most will be gained by reading the book as a whole. Each chapter starts with an abstract overview and concludes with summary bullet points, creating a handy quick check for key points. This accessible text is for those who are interested in supporting alert and safe transportation operations. It is suitable for professionals, transport managers, government advisors, policy makers, students, academics, and anyone who wants to learn more. All transport modes (road, rail, maritime and aviation) are considered. For anyone waking up to the complex challenge of fatigue management, this handbook is a must.