Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include:an introduction to  fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort.setting up an FBDD projectlibrary building and productionNMR in fragment screening and follow upapplication of protein-ligand NOE matching to the rapid evaluation of fragment binding posestarget immobilized NMR screening: validation and extension to membrane proteinsin situ fragment-based medicinal chemistry: screening by mass spectrometrycomputational approaches to fragment and substructure discovery and evaluationvirtual fragment scanning  current trends, applications and web based toolsfragment-based lead discovery using covalent capture methodscase study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generationWith contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.