This handbook is an up-to-date, evidence based quick, easy reference guide for expert regional anesthesia providers. It will also be an invaluable tool and a great entry point for amateurs' sonographers who wish to understand the basics of ultrasound, its uses for diagnosis and treatment, current guidelines and standards of care. It presents in details challenges, stratification of risks, techniques, and approaches to facilitate effective ultrasound use in perioperative pain control and emergency room pain management. This uses an outline, schematic approach for easy understanding and retention. The applications of ultrasound are vast and cover the full spectrum of ultrasound guided regional anesthesia. This book concentrates and encompasses the most clinically relevant information as a first aid use of perioperative ultrasound. The chapters are concise, focusing on clinical presentations, diagnosis, differential diagnosis which will help you to deliver patient care in a timely and skillful manner. This compact book is packed with relevant, remarkable information related to ultrasound guided techniques and evidence-based protocols and latest guidelines for regional anesthesia, nerve blocks, and opioid-reducing analgesia to promote early recovery after surgery. Concise, practical, and clinically applicable for various specialties, this book fills the unmet need for understanding the usefulness and techniques of ultrasound and its application in perioperative pain management, in particular regional anesthesia and nerve blocks. This handbook enables every physician, nurse, resident and all medical staff to understand the essentials of ultrasound and regional anesthesia, its evolving techniques, and the use of modern equipment to provide patient care safely.