Key Features Organization of infection control program in Indian context included. Major HAI types such as CAUTI, CRBSI, VAP and 551 covered, giving insight into pathogenesis, laboratory diagnosis, treatment and prevention. HAI surveillance elaborated according to patient safety component manual, NHSN-CDC 2019, covering common terminologies, surveillances of CAUTI, CLABSI, VAE (including latest concept of PedVAE) and 551, and data collection and analysis. Step-by-step illustrations and numerous problem solving exercises included for better understanding of the concept. Standard precautions such as hand hygiene, personal protective equipment along with detailed elaboration on transmission based precaution included. Infection control in special situations or infection type such as transplant units, dialysis units, ICUs, operation theater and outpatient department, autopsy, infection with C. difficile, M. tuberculosis, viral hemorrhagic fever, Legionel/a, etc. included. Disinfection policy covering various areas such as Spaulding's classification of devices and HiTouch areas disinfection, housekeeping policy, endoscopy reprocessing, spillage management, reuse of single use device and disinfectant testing. Environmental surveillance (air, water and surface including endotoxin detection method) and screening for MDROs included. Infection control policy at CSSD (including sterilization indicators), laundry and kitchen included. Biomedical Waste Management covered according to 2016 guidelines with inclusion of 2018 amendment. Infection control requirement for NABH accreditation included. Staff health issues included-needle stick injury (NSI), work restriction and immunization for healthcare professionals including CDC strategies for hepatitis B vaccination. Outbreak investigation included. Antimicrobial Stewardship Programme (AMSP) covering strategies of AMSP, role of laboratory stewardship, antimicrobial policy and monitoring of AMSP.