As the title suggests, this summarizes our approach at Sankara Nethralaya to the management of clinical entities commonly encountered in our ophthalmic practice. It is neither intended to be a formal textbook, nor it is meant to imply that other methods of treatment prescribed and practiced elsewhere are incorrect. The endeavor has been to create guidelines that are rational, practical and relevant to the Indian context. It combines the time-tested recipes of a 25-years clinical experience at Sankara Nethralaya with updated concepts of evolving thought processes all over the globe Step-by-step format in summarizing approach to the management of commonly encountered diseases.Covers topics related to orbit, squint, cornea, glaucoma, uvea, neuro-ophthalmology, vitreoretinal diseases and ocular traumaHistory of every disease is given first followed by indication, contraindication, examination, management (both medical and surgical), treatment and follow up in a bulleted approach style.Current edition includes new section on Orbit and Oculoplasty, Squint and a new chapter on Guidelines for Target Intraocular Pressure in the Glaucoma section.For some of the injuries like chemical injuries etiology, pathophysiology, classification are also given