heralds a new era in pain management. Pain medicine or pain management is recognized as thirty-fourth specialty in the USA and as a separate specialty in many other countries. Unfortunately there are no separate clinical methods developed for this specialty. Pain medicine is strengthening and a larger number of physicians are now taking to pain management, though they are evaluating the patients in their own ways. There is a desperate need of systematic way of evaluation of the patients suffering from pain. Pain medicine started as a palliative care with the intention just to give pain relief in incurable disease. Later, it broadened its approach to cure other painful curable diseases too. There is a definite need to make diagnosis of the painful conditions, and follow a systematic approach of evaluation of patients suffering from pain. This book makes the first attempt to develop clinical methods in pain medicine based on analysis and compilation of available literature and clinical methods in other similar specialties. The book covers regional symptoms like headache, neck pain, low back pain, etc. Each chapter includes separate section to identify red flags or danger signals, flowcharts or algorithms to narrow diagnosis, and suggested investigations to confirm diagnosis.The second edition presents thoroughly revised and updated text; some chapters have been completely rewritten to accommodate recent scientific information and facts useful to the clinicians.