Thereare many different ways to treat complex chronic middle ear disease,with ongoing advancements being made globally. Diverse approaches arenecessitated for variations in patient age, degree of infection, extentof middle ear remodeling, inflammation severity and underlyingmechanisms of Eustachian tube dysfunction. Addressing multinational andclinical nuances, the editors have compiled 48 chapters with eclecticperspectives from otology experts in 13 countries. Thesurgical anatomy of the middle ear cleft and mastoid and underlyingpathophysiological mechanisms of chronic otitis media are clinicallychallenging. Articles cover anatomy, physiology, diseasecharacterizations and manifestations, clinical evaluation, officemanagement, surgical procedures and new horizons. Traditional andnewer hybrid techniques for systematic disease and inflammatoryconditions are presented in roundtable format, for example, underlayfascia tympanoplasty as well as the use of cartilage and bioengineeredmaterials.Selected Key Topics:Applied middle ear anatomy and physiologyPathologic mechanisms of chronic otitis media Office evaluation, management and surgical decision makingMastoid cavity obliteration and canal wall reconstructionChallenges in tympanoplasty and ossicular chain reconstructionTraditional and hybrid tympanomastoid surgeryHearing implants in the chronic earThisis an exceptional teaching tool for ear surgeons in training as well asa must-have clinical resource for practicing otolaryngologists.